Karen Handel — VP for public policy at Susan G. Komen for the Cure — has resigned... why?

She'd been on the side of cutting off funding to Planned Parenthood:

A person with direct knowledge of decision-making at Komen's headquarters in Dallas said the grant-making criteria were adopted with the deliberate intention of targeting Planned Parenthood....

According to the person, who spoke on condition of anonymity for fear of repercussions, a driving force behind the move was Handel, who was hired by Komen last year as vice president for public policy after losing a campaign for governor in Georgia in which she stressed her anti-abortion views and frequently denounced Planned Parenthood....

Handel, a Republican, ran for Georgia governor in 2010, winning an endorsement from former vice presidential candidate and Alaska Gov. Sarah Palin. Handel then lost a primary runoff to former Georgia Congressman Nathan Deal, who won the general election.

Throughout the campaign, Deal accused Handel of being soft on abortion.

Deal repeatedly attacked Handel over a 2005 vote she took while serving on a metro Atlanta county commission to give more than $400,000 to Planned Parenthood....

Abortion politics. It's hard to position yourself in the middle, as it seems Handel has done, and she's managed to get slammed from one side and then the other and to lose 2 big jobs.